Clinically Relevant Pharmacogenomic Testing in Pediatric Practice

Psychiatric pharmacogenomic testing in clinical practice

The clinical adoption of psychiatric pharmacogenomic testing has taken place rapidly over the past 7 years. Initially, drug-metabolizing enzyme genes, such as the cytochrome P450 2D6 gene (CYP2D6), were identified. Genotyping the highly variable cytochrome P450 2D6 gene now provides clinicians with the opportunity to identify both poor metabolizers and ultrarapid metabolizers of 2D6 substrate m...

Clinically actionable genotypes among 10,000 patients with preemptive pharmacogenomic testing

Since September 2010, more than 10,000 patients have undergone preemptive, panel-based pharmacogenomic testing through the Vanderbilt Pharmacogenomic Resource for Enhanced Decisions in Care and Treatment program. Analysis of the genetic data from the first 9,589 individuals reveals that the frequency of genetic variants is concordant with published allele frequencies. Based on five currently im...

Lessons Learned When Introducing Pharmacogenomic Panel Testing into Clinical Practice.

OBJECTIVES Implementing new programs to support precision medicine in clinical settings is a complex endeavor. We describe challenges and potential solutions based on the Indiana GENomics Implementation: an Opportunity for the Underserved (INGenious) program at Eskenazi Health-one of six sites supported by the Implementing GeNomics In pracTicE network grant of the National Institutes of Health/...

Guideline on good pharmacogenomic practice

Clinically relevant variations in the origin and course of the radial artery

Background: The radial artery is an essential artery supplying the structures in the forearm. Variations in the radial artery concerning its origin, course, branching pattern, and mode of termination have been commonly reported. The high origin of the radial artery from either brachial or axillary artery was detected in numerous studies. Clinically-radial artery is used in cardiac catheterizati...